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阿尔茨海默病研究: “整体观”的启示和探索

发布时间: 2019-09-21 16:23:39|来源:BBIN真人_bbin真人游戏-官网APP下载

BBIN真人  9YUE21RISHI“SHIJIEAERCIHAIMOBINGRI”。ZUOWEIYIZHONGJIHUANZHEBENRENHEJIASHUDAILAIJUDATONGKUHECHENZHONGFUDANDESHENJINGTUIXINGXINGJIBING,AERCIHAIMOBING(AD)YIZHIMIANLINYOUXIAOZHILIAOSHOUDUANKUIFADEJUMIAN。JUDADEHUANZHEQUNTIJIGUOJIAHESHEHUIDAILAILECHENZHONGDEJINGJIFUDAN。QUANQIUGEDAZHIYAOGONGSIZAIGUOQUDEJIN20NIANLI,TOURUSHUQIANYIMEIYUANYANFAKANGADYAOWU,DANJUNYISHIBAIGAOZHONG。

  YIKUANXINYAODEYANFABAOHANXUDUOJISHUHUANJIE,DATISHANGKEFENWEIFAXIANHEKAIFALIANGGEJIEDUAN。XINYAOFAXIANJIEDUAN,YOUKEXIFENWEIYAOWUZUOYONGBADIAN(JIZHI)DEFAXIANHEQUEREN、XIANDAOHUAHEWUDEFAXIANHEYOUHUA、HOUXUANXINYAODECHUBUPINGJIAHEQUERENDENGHUANJIE。XINYAOKAIFAJIEDUANDERENWU,BAOKUOWANCHENGXINYAODELINCHUANGQIANYANJIUBINGXIANGGUOJIASHENBAOLINCHUANGYANJIUPIJIAN,HUODEPIZHUNHOUKAIZHANXINYAOLINCHUANGYANJIUHEPINGJIA,TONGCHANGBAOKUOⅠ、Ⅱ、ⅢQILINCHUANGSHIYAN。YIBANQINGKUANGXIA,ZHEIGEGUOCHENGXUYAO8NIANZHI10NIAN。

BBIN真人  ZAIMANZHANGDEXINYAOYANFAGUOCHENGZHONGHUIYUDAOXUDUOKEXUEHEJISHUNANTI。BIRU,YAOWUZUOYONGBADIAN(JIZHI)DEFAXIANHEQUERENSHISHAIXUANHEFAXIANHUOXINGHUAHEWUDEJICHU,XUYAODUIJIBINGFASHENG、FAZHANDEXIBAO—FENZIJIZHIYOUSHENRUHEZHENGQUEDELEJIE,TASHEJIDAOSHENGMINGKEXUE、YIXUEJICHUYANJIUDEXINFAXIANHEXINTUPO。RUGUODUIYAOWUZUOYONGBADIANDERENSHIYOUPIANCHA,ZHENGGEYAOWUFAXIANHEYANJIUGONGZUOJIUHUIWURUQITU。YOURU,ZHENDUIBADIANKAIZHANYAOWUSHEJI,XUYAOZAIBADIAN(SHOUTI、MEI、BINGDUDANBAIDENG)SANWEIJIEGOUJICHUSHANGKAIZHANJISUANJIXUNISHAIXUAN,HAIXUYAOJIANLILINGMINGAOXIAODEYAOLIXUEPINGJIAMOXINGJINXINGHUAHEWUDEPINGJIAHEYOUHUA,ZHEIJIUXUYAOJIEGOUSHENGWUXUE、JISUANJIXUNISHAIXUANJISHUHEXIANDAIYAOLIXUE(XIBAO—FENZISHENGWUXUE)JISHUDEPEIHE;DUIYUHOUXUANYAOWUFENZICHENGYAOXINGDEPINGJIA,YEXUYAOLILUNYUCEFANGFAHESHIYANYANJIUDEJIEHE。CIWAI,LINCHUANGQIANYANJIUJIEDUANZAIXIBAO—FENZIHEDONGWUMOXINGSHANGDEDAODEJIEGUO,DAOLELINCHUANGJIEDUANZAIRENSHENSHANGJINXINGSHIYANSHI,WANGWANGBUNENGDEDAOYUXIANGDEYANZHENG,YESHIXINYAOYANFAZHONGJINGCHANGYUDAODEWENTI。

  AD药物研发的三个阶段

  和中国科学家的探索

BBIN真人  CONGQUANQIUFANWEIKAN,ADYAOWUDEYANFALICHENGDATIJINGLILESANGEJIEDUAN。

BBIN真人  DIYIJIEDUANDEYAOWUYANFAZHUYAOSHIYIADDEBINGYINYUANYUDANJIANNENGSHENJINGYUANGONGNENGYICHANGDELILUNWEIJICHUKAIZHANDE。MUQIAN,GUONEIYIPIZHUNSHIYONGDE5GEZHENGZHUANGLEIGAISHANYAOWUDUONAIPAIQI、QINGXIUSUANJIALANTAMIN、KABALATING、SHISHANJIANJIAHEMEIJINGANGZHONG,CHUMEIJINGANGWAI,QIYU4GEDOUSHUYUYIXIANDANJIANZHIMEIYIZHIJI,QIZHONG1995NIANSHANGSHIDESHISHANJIANJIASHIZHONGKEYUANSHANGHAIYAOWUYANJIUSUODEKEXUEJIACONGZHONGYAOSHISHANSHUZHIWUQIANCENGTAZHONGTIQUCHUDETIANRANSHENGWUJIAN。ZHEILEIYAOKEYIDUANQIGAISHANZHENGZHUANG,DANBINGBUNENGGAISHANJIBINGDEJINCHENG。ZAIZHEIYIJIEDUAN,BBINZHENRENGUODEYANJIUYUGUOJISHIXIANGDANGDE。

  DIERJIEDUANSHIZAIGUOQUJIN20NIANJIAN,RENMENDUIADFABINGJIZHIDELIJIEZHUYAOJIZHONGYUβDIANFENYANGDANBAICHENJIHETauDANBAIGUODULINSUANHUADAOZHIDESHENJINGXIANWEICHANJIESHANG。GUOJIDAZHIYAOGONGSIZHILIYUKAIFAZHENDUIZHEILIANGGEBADIANDEKANGTIHEXIAOFENZIYAOWU。RANER,SHUQIANYIMEIJINDETOURUQIJINWUYICHENGGONG。ZAIZHEIYIJIEDUAN,MIANDUIADLINGYULINCHUANGYANJIUDEGAOSHIBAILV,GUONEIJINYOUHENSHAOYAOQIKAIZHANLEKANGADYAOWUDEYANFA。

  MIANDUIBAXIANGAβHETauDANBAIDEYAOWUYANFADEBUDUANSHOUCUO,YENEIYEZAIBUDUANTANSUO、FANSI。ZAI“HOUAβ”SHIDAI,RUHELIJIE、ZHILIAOAD?

  GANLUTENAJIAONANG(JIUQIYI)SUOJIESHIDENAOCHANGZHOULILUN,JIYOUKENENGJIANGADYAOWUDEYANFADAIRUYIGEXINJIEDUAN。JIUQIYISHI17NIANLAISHOUGECHENGGONGSHANGSHIDEKANGADXINYAO,WEIKANGADYAOWUDEYANFATIGONGQUANXINDESILUYUCELVE。ZUOWEIZHONGGUOYUANCHUANGXINYAO,JIUQIYIDECHENGGONGSHANGSHIWEITUPOADZHILIAOZHEIYISHIJIENANTITIGONGLEKEGONGTANTAOHEJIEJIANDE“ZHONGGUOTANSUO”。

BBIN真人  JIUQIYIDELINCHUANGQIANYANJIUGONGZUOXIANSHI,ADDEBINGYINSHIFUZADE,JUYOUDUOYINSU,QIBUJINYUDANAODANBAIZHEDIECUOWUJIEDAODESHENJINGTUIXINGXINGBINGBIANXIANGGUAN,GENGSHIYIZHONGDANAOJUBUYANZHENGFANYINGYICHANGDAOZHIDEJIBING,ERCHANGDAOJUNQUNSHIHENGJIEDAODEQUANSHENYANZHENG—MIANYIWENLUANYUZHEIZHONGDANAOJUBUYANZHENGFANYINGYICHANGYOUZHEMIQIEDEYINGXIANGHEDIAOKONGGUANXI。

BBIN真人  ZHEIZHONGDUIYUJIBINGZHENGTIGUANDERENSHI,DAPOLEYIWANGZHIGUANZHUNAONEITEDINGDANBAIYICHANGDERENSHIJUXIAN,JIYOUKENENGWEIADZHEILEIMANXINGFUZAJIBINGDEZHILIAODAILAITUPO。

  从“整体观”审视、研究神经退行性疾病

  DUIYURENHEYIZHONGJIBINGDECHENGGONGFANGZHI,DOUSHIYIDUIJIBINGFABINGJIZHIZHENGQUE、QUANMIANDERENSHIHELIJIEWEIJICHUDE。YINCI,ZAISHENJINGTUIXINGXINGJIBINGZHILIAOSHANGYUDAODETIAOZHAN,SHUODAODIHAISHIZAIYUDUIJIBINGFABINGJIZHIRENSHISHANGDEJUXIAN。SHENJINGTUIXINGXINGJIBINGZUOWEIYIZHONGSHUAILAOXIANGGUANDEJIBING,BENSHENJUYOUBINGCHENGMANZHANG、BINGLIJIZHIFUZADETEDIAN。YIWANGDEYANJIUCUNZAIGUOYUJUBUHUA、JIANDANHUADEWENTI,JIANGZHEIYANGYIGEMANXINGFUZAJIBINGJIANDANDIGUIJIEWEIDANAOJUBUDEDANBAIJUJIHUOGUODULINSUANHUA,XIANZAIKANLAIBINGBUNENGQUANMIANDIFANYINGJIBINGFABINGJIZHIDEZHENSHIMIANMAO。

  ZUOWEIRENTIZHONGZUIZHONGYAODESHENGLIYUYISHI、RENZHIDENGJINGSHENHUODONGDEJIAOHUIDIAN,DANAOTONGSHICHENGZAIZHESHENGLIYUJINGSHEN—YISHIDESHUANGZHONGGONGNENG。DANAOJIBINGCHUZAISHENGLIJIEPOUSHUIPINGSHANGKEYIGUANCHADAODEBINGBIANYIWAI,YE(ERQIEWANGWANGGENGMINGXIAN)BIAOXIANWEIYISHI、RENZHIGONGNENGHEXINLISHANGDEGEZHONGYICHANGHEZHANGAI。ERSHENJINGNEIFENMIWANGLUOZUOWEILIANJIEDANAOHEQUANSHENDEDIAOKONGXITONG,QIYUWEISHENGTAI、MIANYI、DAIXIEJIANDEJIAOHUZUOYONGHEYINGXIANGZAIDANAOJIBINGFASHENG、FAZHANZHONGFAHUIZHEBUKEHUSHIDEZUOYONG。YINCI,DUIYUSHENJINGTUIXINGXINGJIBING,JIYAOGUANZHUDANAOZISHENFASHENGDESHENGLI—BINGLIBIANHUA,YEYAOZHUZHONGQUANSHENXITONG(WEISHENGTAI、MIANYI、DAIXIEDENG)DUINAOBUSHENJINGTUIXINGXINGJIBINGFASHENGFAZHANDEYINGXIANG。

BBIN真人  YINCI,BBINZHENRENYAODAPOGAILINGYUZHANGQIYILAISHIJICUNZAIDE“ZHONGJUBU、QINGZHENGTI,HUSHIHEDANHUARENTIZUOWEIYIGEZHENGTIFUZAXITONGDUIJUBUDEYINGXIANG”DEYANJIUJUXIAN,CONG“YIRENWEIBENDEZHENGTIGUAN”DEYANJIUSHIJIAOZHONGXINSHENSHI、YANJIUSHENJINGTUIXINGXINGJIBING。YAOGENGDUODIGUANZHUQUANSHENJITIWEISHENGTAIJUNQUNSHIDIAO、MIANYIYANZHENGWENLUAN、DAIXIEYINGJI、SHENJINGNEIFENMIWANGLUOSHIHENGDENGDUOWEIDUJIAOHUZUOYONGZAINAOBUDETEZHENGXINGBIAOXIAN。ZHEIYANGDEXINSILUYOUKENENGZAISHENJINGTUIXINGXINGJIBINGFASHENGFAZHANBINGCHENGFANGKONGSHANGQUDEZHONGDALILUNTUPO,DAILAIZAOQIZHENDUANYUJINGZHUNGANYUDEBIANGE。

  对于未来研究的建议

  DUIYUWEILAIDEXIANGGUANYANJIU,BBINZHENRENYOUSIGEJIANYI。

BBIN真人  SHOUXIAN,ZUIGENBENDESHIYAOZAIYANJIUGONGZUOZHONGJIANCHIKEXUEJINGSHENHEKEXUETAIDU。QIUZHENSHIKEXUEYANJIUZUIGENBENDEMUBIAO,YESHIDUIKEJIGONGZUOZHEZUIJIBENDEYAOQIU。QIUZHENDEGUOCHENGSHIYIGEBUDUANTANSUO、BUDUANZONGJIE(BAOKUOBUDUANJIUCUO)DEKEXUESHIJIANGUOCHENG。JIYAOJIANCHISHISHIQIUSHI、ZUNZHONGKEGUANDEKEXUEYUANZE,YOUYAOYOUYONGYUTANSUO、GANYUTUPOCHANGGUIDECHUANGXINJINGSHENHEDANSHI。WEICI,KEXUEJIEYAOXINGCHENGYOULIYUKEJICHUANGXINJIANKANGFAZHANDEKEXUEFENWEI。

BBIN真人  QICI,YIDUOWEI、KAIFANGHECHUANGXINDESIWEI,SHENRUYANJIUHEQUANMIANJIESHIADZUOWEIYIZHONGFUZAJIBINGDEFASHENGFAZHANJIZHI。SHISHISHANG,RENLEIDUIADDENGFUZAJIBINGDEYANJIUGUOCHENGYOURUMANGRENMOXIANG,JINGUANMODAODEMEIGEBUWEIDOUSHIZHENSHICUNZAIDE,DANZHIYOUTONGGUODUIGEGEBUWEICAIJIDEXINXIJINXINGQUANJINGSHIDEZHENGHEJIGUANLIANFENXI,CAINENGHUOQUYIGEJIEJINYUANMAODEZHENSHIJIEGUO。YINCI,RENMENDUIJIBINGFABINGJIZHIDERENZHIYAOJINGLIYIGEXIANGDANGMANZHANGDEYANHUAGUOCHENG,ZHEIBINGBUQIGUAI。ADZUOWEIYIZHONGNANZHIXINGMANXINGFUZAJIBING,QIYAOWUYANFAHEZHILIAO,SHISHISHANGJIUSHIYAOJINGLIYIGEBUDUANSHICUO、BUDUANXIUZHENG、BUDUANDIAOZHENG、BUDUANGENGXINDEGUOCHENG。XIANZAIYUELAIYUEDUODEYANJIUTISHI,DUIADFABINGJIZHIDERENSHI,XUYAOYOUGENGJIAKAIFANG、DUOWEIHECHUANGXINDESIWEI。

  ZAICI,YAOJIAQIANGZAOQIZHENDUAN、BINGQINGJIANKONGPINGJIAXINJISHUHEXIANGGUANSHENGWUBIAOZHIWUDEYANJIU。ADZAOQIZHENDUAN、ZHENGZHUANGDEJIANKONGHEPINGGU,QIJINQUEFALINGMINDUGAOHEZHUNQUEXINGGAODEJISHUHEFANGFA,JIXINYAOYANFAHELINCHUANGZHILIAODAILAIXUDUOKUNNAN。JIXUZAIJIBINGFASHENGFAZHANJIZHIYANJIUDEJICHUSHANG,JIAQIANGDUOXUEKEDEJIAOCHARONGHE,ZAIXIANGGUANSHENGWUBIAOZHIWUYANJIUZHONGQUDEJINZHANHETUPO。

  ZUIHOU,YAOJIANCHIZHUANHUAYIXUEHEXUNZHENGYIXUEDELINIAN,JINYIBUWANSHANHETISHENGLINCHUANGYANJIU。YIFANGMIAN,TONGGUOGENGDAGUIMO、JINGZHUNSHEJIDELINCHUANGYANJIU,DUIYAOWUDELIAOXIAOJINXINGGENGSHENRUHEGENGZHUNQUEDEPINGJIA;LINGYIFANGMIAN,ZHENDUIYAOWUDEZUOYONGTEDIAN、YONGYAOGUILVJILEIGENGDUODERENSHIHEJINGYAN,TUIDONGHOUXUYANJIUDEFAZHAN。

  (陈凯先 作者系中国科学院院士)


责任编辑: 孙远进 校对: 北山

ZHONGGUOZHOUKANGUANFANGWEIBO

GUANFANGWEIXINGONGZHONGHAO

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